SrasV1, France, Analysis, bibRecord, 000298

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.

Identifieur interne : 000298 ( France/Analysis ); précédent : 000297; suivant : 000299

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.

Source :

BMC Infectious Diseases [ 1471-2334 ] ; 2006.

RBID : Hal:inserm-00089620

Abstract

BACKGROUND: Host genetic factors may play a role in susceptibility and resistance to SARS associated coronavirus (SARS-CoV) infection. The study was carried out to investigate the association between the genetic polymorphisms of 2',5'-oligoadenylate synthetase 1 (OAS1) gene as well as myxovirus resistance 1 (MxA) gene and susceptibility to SARS in Chinese Han population. METHODS: A hospital-based case-control study was conducted. A collective of 66 SARS cases and 64 close contact uninfected controls were enrolled in this study. End point real time polymerase chain reaction (PCR) and PCR-based Restriction Fragment Length Polymorphism (RFLP) analysis were used to detect the single nucleic polymorphisms (SNPs) in OAS1 and MxA genes. Information on other factors associated with SARS infection was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted. RESULTS: One polymorphism in the 3'-untranslated region (3'-UTR) of the OAS1 gene was associated with SARS infection. Compared to AA genotype, AG and GG genotypes were found associated with a protective effect on SARS infection with ORs (95% CI) of 0.42 (0.20~0.89) and 0.30 (0.09~0.97), respectively. Also, a GT genotype at position 88 in the MxA gene promoter was associated with increased susceptibility to SARS infection compared to a GG genotype (OR = 3.06, 95% CI: 1.25~7.50). The associations of AG genotype in OAS1 and GT genotype in MxA remained significant in multivariate analyses after adjusting for SARS protective measures (OR = 0.38, 95% CI: 0.14~0.98 and OR = 3.22, 95% CI: 1.13~9.18, respectively). CONCLUSION: SNPs in the OAS1 3'-UTR and MxA promoter region appear associated with host susceptibility to SARS in Chinese Han population.

Url:

https://www.hal.inserm.fr/inserm-00089620

DOI: 10.1186/1471-2334-6-106

Affiliations:

France, Pays-Bas, République populaire de Chine

Links toward previous steps (curation, corpus...)

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Hal:inserm-00089620

Le document en format XML

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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Zhang, Panhe" sort="Zhang, Panhe" uniqKey="Zhang P" first="Panhe" last="Zhang">Panhe Zhang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18338" status="INCOMING">          <orgName>State Key Laboratory of Pathogen and Biosecurity</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
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          <desc>            <address>              <country key="CN"></country>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Plancoulaine, Sabine" sort="Plancoulaine, Sabine" uniqKey="Plancoulaine S" first="Sabine" last="Plancoulaine">Sabine Plancoulaine</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2909" status="OLD">          <idno type="RNSR">201019154F</idno>
          <orgName>Génétique Humaine des Maladies Infectieuses</orgName>
          <orgName type="acronym">Inserm U980</orgName>
          <date type="start">2010</date>
          <date type="end">2014</date>
          <desc>            <address>              <addrLine>Fac de Medecine Necker-Enfants Malades 156, Rue de Vaugirard 75730 PARIS CEDEX 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR_S 980" active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD">          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
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              <country key="FR"></country>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18338" status="INCOMING">          <orgName>State Key Laboratory of Pathogen and Biosecurity</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
              <country key="CN"></country>
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        <tutelles><tutelle active="#struct-306858" type="direct"><org type="institution" xml:id="struct-306858" status="INCOMING">          <orgName>Beijing Institute of Microbiology and Epidemiology</orgName>
          <desc>            <address>              <country key="CN"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Zhan, Lin" sort="Zhan, Lin" uniqKey="Zhan L" first="Lin" last="Zhan">Lin Zhan</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18338" status="INCOMING">          <orgName>State Key Laboratory of Pathogen and Biosecurity</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
              <country key="CN"></country>
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          <listRelation>            <relation active="#struct-306858" type="direct"></relation>
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        <tutelles><tutelle active="#struct-306858" type="direct"><org type="institution" xml:id="struct-306858" status="INCOMING">          <orgName>Beijing Institute of Microbiology and Epidemiology</orgName>
          <desc>            <address>              <country key="CN"></country>
            </address>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18338" status="INCOMING">          <orgName>State Key Laboratory of Pathogen and Biosecurity</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
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          <desc>            <address>              <country key="CN"></country>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Wang, Tianbao" sort="Wang, Tianbao" uniqKey="Wang T" first="Tianbao" last="Wang">Tianbao Wang</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18341" status="INCOMING">          <orgName>Beijing General Hospital of Armed Police</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
              <country key="CN"></country>
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          </desc>
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            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Richardus, Jan" sort="Richardus, Jan" uniqKey="Richardus J" first="Jan" last="Richardus">Jan Richardus</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-308157" status="VALID">          <orgName>Erasmus University Medical Center [Rotterdam]</orgName>
          <orgName type="acronym">Erasmus MC</orgName>
          <desc>            <address>              <addrLine>Rotterdam</addrLine>
              <country key="NL"></country>
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        </hal:affiliation>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Habbema, J Dik" sort="Habbema, J Dik" uniqKey="Habbema J" first="J Dik" last="Habbema">J Dik Habbema</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-308157" status="VALID">          <orgName>Erasmus University Medical Center [Rotterdam]</orgName>
          <orgName type="acronym">Erasmus MC</orgName>
          <desc>            <address>              <addrLine>Rotterdam</addrLine>
              <country key="NL"></country>
            </address>
            <ref type="url">http://www.erasmusmc.nl</ref>
          </desc>
        </hal:affiliation>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Cao, Wuchun" sort="Cao, Wuchun" uniqKey="Cao W" first="Wuchun" last="Cao">Wuchun Cao</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18338" status="INCOMING">          <orgName>State Key Laboratory of Pathogen and Biosecurity</orgName>
          <desc>            <address>              <addrLine>Beijing</addrLine>
              <country key="CN"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-306858" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-306858" type="direct"><org type="institution" xml:id="struct-306858" status="INCOMING">          <orgName>Beijing Institute of Microbiology and Epidemiology</orgName>
          <desc>            <address>              <country key="CN"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1186/1471-2334-6-106</idno>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="ISSN">1471-2334</idno>
<imprint><date type="datePub">2006</date>
</imprint>
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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: Host genetic factors may play a role in susceptibility and resistance to SARS associated coronavirus (SARS-CoV) infection. The study was carried out to investigate the association between the genetic polymorphisms of 2',5'-oligoadenylate synthetase 1 (OAS1) gene as well as myxovirus resistance 1 (MxA) gene and susceptibility to SARS in Chinese Han population. METHODS: A hospital-based case-control study was conducted. A collective of 66 SARS cases and 64 close contact uninfected controls were enrolled in this study. End point real time polymerase chain reaction (PCR) and PCR-based Restriction Fragment Length Polymorphism (RFLP) analysis were used to detect the single nucleic polymorphisms (SNPs) in OAS1 and MxA genes. Information on other factors associated with SARS infection was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted. RESULTS: One polymorphism in the 3'-untranslated region (3'-UTR) of the OAS1 gene was associated with SARS infection. Compared to AA genotype, AG and GG genotypes were found associated with a protective effect on SARS infection with ORs (95% CI) of 0.42 (0.20~0.89) and 0.30 (0.09~0.97), respectively. Also, a GT genotype at position 88 in the MxA gene promoter was associated with increased susceptibility to SARS infection compared to a GG genotype (OR = 3.06, 95% CI: 1.25~7.50). The associations of AG genotype in OAS1 and GT genotype in MxA remained significant in multivariate analyses after adjusting for SARS protective measures (OR = 0.38, 95% CI: 0.14~0.98 and OR = 3.22, 95% CI: 1.13~9.18, respectively). CONCLUSION: SNPs in the OAS1 3'-UTR and MxA promoter region appear associated with host susceptibility to SARS in Chinese Han population.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Pays-Bas</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="He, Jing" sort="He, Jing" uniqKey="He J" first="Jing" last="He">Jing He</name>
</noRegion>
<name sortKey="Cao, Wuchun" sort="Cao, Wuchun" uniqKey="Cao W" first="Wuchun" last="Cao">Wuchun Cao</name>
<name sortKey="Feng, Dan" sort="Feng, Dan" uniqKey="Feng D" first="Dan" last="Feng">Dan Feng</name>
<name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name>
<name sortKey="Wang, Hongwei" sort="Wang, Hongwei" uniqKey="Wang H" first="Hongwei" last="Wang">Hongwei Wang</name>
<name sortKey="Wang, Tianbao" sort="Wang, Tianbao" uniqKey="Wang T" first="Tianbao" last="Wang">Tianbao Wang</name>
<name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name>
<name sortKey="Zhan, Lin" sort="Zhan, Lin" uniqKey="Zhan L" first="Lin" last="Zhan">Lin Zhan</name>
<name sortKey="Zhang, Panhe" sort="Zhang, Panhe" uniqKey="Zhang P" first="Panhe" last="Zhang">Panhe Zhang</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="De Vlas, Sake" sort="De Vlas, Sake" uniqKey="De Vlas S" first="Sake" last="De Vlas">Sake De Vlas</name>
</noRegion>
<name sortKey="Habbema, J Dik" sort="Habbema, J Dik" uniqKey="Habbema J" first="J Dik" last="Habbema">J Dik Habbema</name>
<name sortKey="Richardus, Jan" sort="Richardus, Jan" uniqKey="Richardus J" first="Jan" last="Richardus">Jan Richardus</name>
</country>
<country name="France"><noRegion><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name>
</noRegion>
<name sortKey="Plancoulaine, Sabine" sort="Plancoulaine, Sabine" uniqKey="Plancoulaine S" first="Sabine" last="Plancoulaine">Sabine Plancoulaine</name>
</country>
</tree>
</affiliations>
</record>

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Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.

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